Relationship between blood inflammatory monocytes and brain severity after cerebral infarction/cerebral hemorrhage

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18393
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Ehime University
• Principal Investigator: Abe Naoki 愛媛大学, 医学系研究科, 講師 (10512155)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 脳出血 / 単球 / Ly6C / CD11c

Outline of Final Research Achievements

With the inflammatory markers(Ly6C) used in this study, changes in the properties of brain-infiltrating monocytes could not be detected from blood monocytes. As shown in this study, monocytes that infiltrate the brain change from inflammatory properties in the hyperacute phase to dendritic cell-like properties in the subacute phase. Thus, the properties of brain-infiltrating monocytes are changing rapidly. Therefore, treatment to suppress secondary brain damage due to inflammation may increase complications and worsen the prognosis if the timing of treatment is incorrect. In order to confirm whether there are markers in the blood that can evaluate changes in the brain, it is necessary to collect cell populations at each stage and perform a total analysis of mRNA to determine whether such markers really exist.

Free Research Field

脳神経科学

Academic Significance and Societal Importance of the Research Achievements

血液中単球の性質変化と脳の損傷程度が相関した場合、急性期の血液中の単球の性質を調べるだけで、脳の二次的損傷損傷（過剰な炎症による損傷）の大きさを予測でき、積極的に抗炎症療法などの治療介入が必要な状態かどうかを評価できる可能性がある。さらに、その性質の単球は治療のターゲットとなりうる可能性があったため、臨床検体を用いた実験と動物実験を行ったが、今回用いた炎症性マーカーでは脳内のの二次的損傷の状態を評価することができなかった。