Involvement of inflammation in the acute phase of stroke.

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K18395
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kumamoto University
• Principal Investigator: Amadatsu Toshihiro 熊本大学, 大学院生命科学研究部(医), 特定研究員 (80838665)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: cerebral ischemia / moyamoya disease / collagen matrix

Outline of Final Research Achievements

The study was planned to collect samples from patients with cerebral infarction and to analyse their molecular biology, but due to the Covid-19 outbreak it was not possible to collect samples for the experiment and the study could not be carried out. Analysis will be carried out on the samples collected in the future.
Basic experiments that seemed promising were carried out. Revascularisation is performed for MMD. In rats with chronic cerebral hypoperfusion, indirect bypass with an absorbable artificial dura mater using DuraGen showed an increase in vascular endothelial cells comparable to that of conventional indirect bypass using the temporal muscle; the use of DuraGen in actual indirect bypass procedures in patients with MMD preserved the normal subcutaneous tissue layer; and the use of DuraGen in the treatment of MMD was associated with the prevention of surgical complications such as impaired wound healing and alopecia.

Free Research Field

neurosurgery

Academic Significance and Societal Importance of the Research Achievements

もやもや病患者に対する実際の間接バイパス術において、側頭筋を含む皮下組織の代わりにDuraGen;を使用することで、正常な皮下組織層を温存し、創傷治癒不全や脱毛などの手術合併症を予防したうえで、従来の間接バイパス術と同様の血管新生をもたらす可能性がある。