Investigation of functional network using subdural electrodes made by an Au-Pt alloy

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18424
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: Kyoto University
• Principal Investigator: YAMAO YUKIHIRO 京都大学, 医学研究科, 助教 (90736810)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 覚醒下手術 / 脳機能 / 頭蓋内電極 / MRI / 術中マッピング

Outline of Final Research Achievements

In this study, we prepared new sheet-type subdural electrodes using an Au-Pt alloy, which did not generate magnetic susceptibility artifacts even in 3 tesla MRI. Although we did not perform the product specifications due to the elevated cost of an Au-Pt alloy, we implanted the electrode in the brain surface of a few patients, and evaluated the usefulness and safety of the new electrode device when intraoperative 3 tesla MRI was performed.
To map the brain function, we also demonstrated that cortico-cortical evoked potentials (CCEPs) method provides the efficiency of intraoperative monitoring only under general anesthesia.

Free Research Field

脳神経外科

Academic Significance and Societal Importance of the Research Achievements

MRIでアーチファクトの少ない合金を用いて頭蓋内電極を開発できたことは、今後の術中脳機能マッピングの一助となると考えられ、脳内ネットワークの解明に貢献できる可能性を有する。臨床的には脳神経外科術後の脳機能温存にも貢献できうると考えられる。