2020 Fiscal Year Final Research Report
Elucidation of transcription factors that suppress glioma
| Project/Area Number |
19K18446
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | グリオーマ / AMPA受容体 |
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| Outline of Final Research Achievements |
The presence of cancer stem cells is drawing attention as a cause of cancer recurrence. In this study, we established cancer stem cells from surgically resected gliomas. Then, we found glioma stem cell lines in which proliferation was suppressed by the antiepileptic drug perampanel. RNA sequence analysis revealed the expression of AMPA3 receptor in the glioma stem cells. MEF2A and GATA4 were identified as the transcription factors. These results suggest that the AMPA3 receptor may be a potential therapeutic target for glioma.
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| Free Research Field |
脳神経外科学
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| Academic Significance and Societal Importance of the Research Achievements |
グリオーマは強い浸潤能がある。そのため、腫瘍細胞は脳の正常部位に深く染み渡り、外科手術では全摘出できない。さらに化学療法と放射線治療の集学的治療を行っても、治療抵抗性をもつがん幹細胞が増殖をくりかえす。再発の根源であるがん幹細胞をターゲットとした治療法は有効であると考えられる。本研究成果は、がん幹細胞が発現する受容体と転写因子を明らかにした。これらの分子は、グリオーマの治療の標的になりうると考えられる。
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