Mechanism of epileptogenesis in normal neuron around low-grade epilepsy-associated neuroepithelial tumors

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K18448
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56010:Neurosurgery-related
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Iijima Keiya 国立研究開発法人国立精神・神経医療研究センター, 病院, 医員 (10751878)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: てんかん / 脳腫瘍 / GABA / 神経伝達物質 / LEAT

Outline of Final Research Achievements

From 1998 to 2021, ninety-three pathological samples were diagnosed as low-grade epilepsy-associated tumors. We got consent for research participation in 68 patients. Two samples were excluded from analysis due to insufficient specimen amount. We identified genotype in 51 patients (32 BRAF V600E mutant, 10 FGRFR1 mutant and 9 the other genotypes). In 12 patients, we could quantify the concentration of GABA, glycin and glutamate in both tumor and surrounding normal tissue.

Free Research Field

てんかん原性腫瘍

Academic Significance and Societal Importance of the Research Achievements

本研究では、貴重な脳神経外科手術検体を用い、低悪性度てんかん原性腫瘍およびその周囲の正常組織において、主要な興奮性神経伝達物質であるグルタミン酸、抑制性神経伝達物質であるGABAおよびglycinの濃度を測定することに成功した。この知見は低悪性度てんかん原性腫瘍の周囲におけるてんかん現象の発生機構の解明につながり、新規抗てんかん治療の開発に寄与する。