Piezo1 are involved in coordination of angiogenesis and osteogenesis

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18468
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Saga University
• Principal Investigator: Nishiyama Megumi 佐賀大学, 医学部, 助教 (00802844)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: メカノバイオロジー / イオンチャネル / 骨代謝 / 血管新生 / 血管内皮細胞 / 骨芽細胞 / 破骨細胞 / 骨粗鬆症

Outline of Final Research Achievements

The role of local blood flow in bone mass homeostasis is still unclear. Recently, type H vessels that strongly express CD31 and Endomucin were reported to be located at the osteochondral junction and endosteum, which are the front lines of endochondral ossification. These vessels have high angiogenic and osteogenic induction abilities. In this study, we hypothesized that endothelial cells of type H vessels express mechanosensor molecules and are activated by sensing hemodynamic load, contributing to angiogenesis and osteogenesis. To identify the mechanosensor molecules and elucidate the mechanisms involved, we performed morphological expression analysis of mechanosensor molecules in osteochondral and endosteal vessels of fetal mice and osteoporotic model mice, and found expression of several ion channels, suggesting their involvement.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

適度な運動が骨量を維持することは一般によく知られている。昨今の臨床分野では運動と
同様の効果を示す運動模倣薬の登場が待たれている。本研究の成果は骨形成作用を期待し力学刺激を模倣する治療として、メカノセンサーイオンチャネル作動薬を用いた薬理的刺激が新たな治療選択肢となる可能性を示唆する。