2020 Fiscal Year Final Research Report
Physiological role of cyclooxygenase 2 in the uterus
| Project/Area Number |
19K18630
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 着床 / 妊娠 / COX2 / プロスタグランジン |
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| Outline of Final Research Achievements |
The mechanism of embryo invasion, which is the process that the embryo invades into the endometrium, has not been clarified so far. This study focused on embryo invasion and analyzed using COX2 uterine-specific knockout mice. We revealed that COX2 controls embryo invasion via prostaglandins. Furthermore, we revealed that COX2-induced prostaglandins enhance the invasive capacity of trophoblast cells, and promote decidualization. This study revealed that COX2 is a critical uterine factor that regulates the process of embryo invasion.
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| Free Research Field |
産婦人科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、子宮特異的なCOX2欠損マウスを用いることでこれまでのマウスモデルの欠点を克服し、着床をコントロールしているCOX2による子宮の脂質機能調節機構の詳細を明らかにした。胚が子宮内膜に着床する過程、特に胚が子宮内膜に浸潤していく過程とそれに関わる脂肪酸をin vivoで解析することを通して、胚浸潤という現象を脂質生化学的に理解することができた。将来的には着床障害の診断治療への応用に繋がる成果が得られた。
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