Elucidation of Factors Promoting Wound Healing in Postoperative Nasal Mucosa and Establishment of Functional Reconstruction Method Using Cell Sheets

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K18746
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Omura Kazuhiro 東京慈恵会医科大学, 医学部, 講師 (90599713)
• Project Period (FY): 2022-12-19 – 2024-03-31
• Keywords: mucosal healing / epithelization / bony regrowth / inflamation / animal research

Outline of Final Research Achievements

A wound healing model was created using rabbits. Specifically, they compared epithelialization in a mucosa graft with blood flow over the nasal septal cartilage and in a free-flowing mucosa graft without blood flow, and found that blood flow is a useful factor in epithelialization. Specifically, if there is no blood flow to the graft for transplantation, blood flow is required at the base of the graft. If there is blood flow to the graft, blood flow at the foundation does not contribute significantly to epithelialization. In addition, we reported differences in wound healing between different types of wound dressings and factors that promote healing. A study on epithelialization of nasal mucosa sheets was also conducted and the results are being prepared for publication.

Free Research Field

Rhinology

Academic Significance and Societal Importance of the Research Achievements

鼻副鼻腔を手術した患者の術後の創傷治癒を促進する因子がわかったことにより、術後の創傷治癒が悪く慢性的な痂皮で困っている患者や、炎症による骨増生で困っている患者を減らすことができる。