2022 Fiscal Year Final Research Report
Identification of RNA splicing variants that cause head and neck squamous cell carcinoma to highly malignancy.
Project/Area Number |
19K18804
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56050:Otorhinolaryngology-related
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Research Institution | Osaka University |
Principal Investigator |
Kitamura Koji 大阪大学, 大学院医学系研究科, 招へい教員 (40804365)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | 頭頸部扁平上皮癌 / RNAスプライシング |
Outline of Final Research Achievements |
We demonstrated that the splicing regulator SF3B2 is involved in the regulation of gene expression in mitochondrial electron transport pathways and transcriptional regulatory regions by altering its expression level. In addition, SF3B2 regulates gene expression not only by binding to mRNA precursors and regulating splicing, but also by binding to chromatin regions and regulating transcription, suggesting that these molecular mechanisms are involved in the progression of squamous cell carcinoma of the head and neck. These results suggest that these molecular mechanisms through high expression of SF3B2 are involved in the progression of squamous cell carcinoma of head and neck.
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Free Research Field |
頭頸部癌
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Academic Significance and Societal Importance of the Research Achievements |
頭頸部扁平上皮癌は喫煙、飲酒が原因となり発生する予後不良な疾患である。近年、ゲノムワイド関連解析が行われるようになり、がん抑制遺伝子p53などの遺伝子変異がHNSCCの発癌に関連することが明らかにされつつある。しかし、HNSCCの悪性度を規定する分子メカニズムについてはまだ不明である。そのため、HNSCCの治療はその解剖学的進展度に基づいて行われ、分子生物学的な悪性度に応じた治療法は確立されていない。本研究ではHNSCCを高悪性化させる分子メカニズムの一端を明らかにしたことで新たな治療法の開発につながる意義ある研究であったと考える。
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