2021 Fiscal Year Final Research Report
Development of the new treatment of the laryngeal papilloma by host phosphoenzyme inhibition
Project/Area Number |
19K18812
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 56050:Otorhinolaryngology-related
|
Research Institution | Fukushima Medical University |
Principal Investigator |
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Keywords | 喉頭乳頭腫 / 宿主リン酸化酵素 |
Outline of Final Research Achievements |
It was intended to determine three points of the next in this study.(1)Making patient-derived xenograft of the laryngeal papilloma (2)Making the cultured cell model of the laryngeal papilloma (3)Suppression of the laryngeal papilloma by the phosphoenzyme inhibition of the host. The laryngeal papilloma tissue which we obtained by surgery was transfused into a super immunodeficiency mouse, but did not lead to the survival of tumor.Also, we tried culture in the state that embedded a papilloma tissue to mark Rigel or collagen, but the growth of epithelial cells was not confirmed.
|
Free Research Field |
耳鼻咽喉科学
|
Academic Significance and Societal Importance of the Research Achievements |
今回の研究では、目的としていたpatient-derived xenograftの作成および培養細胞モデルの樹立には至らなかった。今後培養条件等を再検討し、引き続き研究をすすめる所存である。 本研究を進めることで、難治性疾患である喉頭乳頭腫の治療について新展開が期待できる。
|