A role of RORa in regulatory T cells with allergic rhinitis

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K18820
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Nippon Medical School
• Principal Investigator: Hosoya Kei 日本医科大学, 医学部, 助教 (20557508)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: アレルギー性鼻炎 / RORA

Outline of Final Research Achievements

Allergic rhinitis has an incidence of nearly 50% in Japan, and there is an urgent need to establish new treatment methods. We focused on RORA (RAR Related Orphan Receptor A) as a causative gene of allergic rhinitis. Using mucosa of the inferior nasal turbinate collected during surgery, we measured RORA in the mucosa and cytokines IL-4 and IL-13, which play an important role in Type 2 inflammation. Comparing samples collected from allergic and non-allergic rhinitis patients, IL-4 was significantly elevated in allergic rhinitis patients. However, for RORA and IL-13, there was a trend toward higher levels in allergic rhinitis patients, but there is no significant difference between two groups.

Free Research Field

アレルギー性鼻炎

Academic Significance and Societal Importance of the Research Achievements

アレルギー疾患の発症にはゲノムワイド関連研究などから遺伝子異常が指摘されている。アレルギー性鼻炎においても41の原因遺伝子が報告されており、RORAはその１つである。本研究では、アレルギー性鼻炎患者と非アレルギー性鼻炎患者でRORAの発現に有意差は認めなかった。非アレルギー性鼻炎と診断した中に局所でアレルギー反応を起こすLocal allergic rhinitisが含まれている可能性があり、Local allergic rhinitisの適切な診断について今後の検討が必要である。