2022 Fiscal Year Final Research Report
Establishment of selective retrograde perforator angiography and developments in serratus anterior rib composite flap.
| Project/Area Number |
19K18906
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56070:Plastic and reconstructive surgery-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 脈管解剖 / 造影剤 / 乳化技術 |
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| Outline of Final Research Achievements |
We found a blood vessel (skin perforators) that rises from a relatively large blood vessels in the deep parts of the body, and a contrast medium was injected retrogradely into the blood vessels, and an attempt was made to survey the running of the blood vessel and the blood perfusion area of the skin. However, as there is no contrast medium that is considered appropriate for use in this type of study, we first developed such a contrast medium. We were successful in developing a contrast medium that is appropriate for use in imaging the minute structures of blood vessels and lymph ducts by emulsifying oil-based iodine contrast medium into surfactant with purified water.
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| Free Research Field |
形成再建外科
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| Academic Significance and Societal Importance of the Research Achievements |
形成外科領域における移植組織の血管解剖やリンパ管解剖（併せて脈管研究という）は、組織移植の成否や病態解明において非常に重要な分野である。これらの研究においては対象となる血管やリンパ管に直接造影剤を注入し、皮下におけるその走行や分布が調査されてきた。従来から脈管研究には種々の造影剤が用いられてきたが、安全性や造影効果、粘性などにおいて一長一短があった。今回我々が開発した造影剤は安全性、造影効果、粘性いずれも従来の造影剤と比較し同等かそれ以上の性質を有していることが確認された。従って、本造影剤を用いることで、安全で、より鮮明かつ簡便に脈管解剖研究が行えるようになることが期待される。
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