Study on the creation of recipient vessels covering the trunk and morphological changes

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18920
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Nippon Medical School
• Principal Investigator: KUWAHARA HIROAKI 日本医科大学, 医学部, 講師 (30614820)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 再建手術 / マイクロサージャリー / レシピエント血管 / 遊離皮弁

Outline of Final Research Achievements

Since the number of anastomosis and the time of preparation are reduced compared to the venous graft, it was possible to shorten the operation time and create a recipient blood vessel that can be expected to be highly safe.
The blood vessels of the rats used were extra-small (the average of the arteries and veins of the flap was 0.50 mm and 0.48 mm, respectively, the average inguinal artery blood vessel diameter was 0.8 mm, and the inguinal vein diameter was 0.7 mm). The flaps were completely engrafted in all cases, except for complications that were thought to be due to the very fine blood vessels and the absence of anticoagulants.

Free Research Field

形成外科、マイクロサージャリー

Academic Significance and Societal Importance of the Research Achievements

ループ血管の概念は透析患者でのシャント血管として広く知られる形態であり安全性が証明されている方法論である。悪性腫瘍切除や外傷などによって人体に大きな欠損(遊離皮弁が必要)が生じてかつ適切なレシピエント血管が存在しない場合に、静脈移植のほかにループ血管作成という選択肢が増した。血行動態や血管吻合への圧力などに関しては選択肢た血管や吻合レベルでさらに研究解析を行っていく必要があるものの、シピエント血管不足時に静脈グラフトを求めるよりも術時間の短縮や合併症の低減が期待できる方法であると考えられ臨床応用が期待される。