Significance of another type of fatty acid-binding protein's expression in septoclastic cartilage resorption

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18949
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Meikai University
• Principal Investigator: BANDO Yasuhiko 明海大学, 歯学部, 講師 (80735548)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: septoclast / E-FABP / A-FABP / PPARγ / growth plate / mouse

Outline of Final Research Achievements

Adipocyte fatty acid binding protein (A-FABP, FABP4) was expressed in a substantial number of septoclasts, growth plate cartilage resorptive cells, originally expressing epidermal FABP (E-FABP, FABP5). Morphologically normal FABP4-positive septoclasts were increased and peroxisome proliferator activated receptor (PPAR) γ was newly expressed in septoclasts in FABP5 knockout mice whose septoclasts are morphologically abnormal. These results suggest that down-regulation of cartilage resorption by septoclasts in FABP5-deficiency can be compensated by increase of FABP4-positive septoclasts mediated by PPARγ.

Free Research Field

口腔解剖・組織・発生学

Academic Significance and Societal Importance of the Research Achievements

本研究結果は原著論文Bando et al. Histochem. Cell Biol. (2021) 155:439-449とレビューBando et al. J Oral Biosci. (2022) 64:18-25で公表された。本研究ではこれまでほとんど報告されていない成長板軟骨吸収細胞septoclastの解析を行った。Septoclastに発現する複数の脂肪酸タンパク質の発現バランスと軟骨吸収能の関係が明らかになることによって、脂肪酸摂取と長管骨成長の関連に新しい理解を得る一助になることが期待できる。