2021 Fiscal Year Final Research Report
Establishment of innovative control method in oral squamous cell carcinoma from sphingolipid
Project/Area Number |
19K18972
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 57020:Oral pathobiological science-related
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Research Institution | Tsurumi University |
Principal Investigator |
KATO Koichiro 鶴見大学, 歯学部, 非常勤講師 (30719373)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 口腔がん |
Outline of Final Research Achievements |
Expressions of sphingosine kinase-1 (SphK1) and sphingosine 1-phosphate receptor (S1PR) were examined in 73 tissues of the squamous cell carcinoma of the tongue. immunohistochemically, and correlations between their expressions and relationships with tumor invasiveness was analyzed. SphK1 was higher expressed in the tumor cells of 35 of 73 tissues of the squamous cell carcinoma of the tongue, particularly at the invasion front. Patients with tongue cancer with high SphK1 expression showed higher invasive grades. In addition, S1PR4 was high expression with Sphk1, these results demonstrate the involvement of SphK1 in the invasiveness of the squamous cell carcinoma of the tongue.
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Free Research Field |
口腔がん
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Academic Significance and Societal Importance of the Research Achievements |
SphK1の高発現は強い浸潤様式を示す舌扁平上皮癌と一致する傾向がみられた。浸潤様式は、以前より臨床的に生命予後へ影響を及ぼす転移との関連性が報告されており、SphK1高発現は舌扁平上皮癌の腫瘍進展を評価するうえで重要な客観的因子となり、また生命予後を推測し得る可能性が考えられた。また、S1PRの発現は細胞により大きく異なるが、S1PR 4はSphk1と同様の高発現を認めたことから、舌扁平上皮癌患者の適切な治療選択の指標に役立ち、さらに治療抵抗性患者に対する今後の標的因子となり得る可能性が示唆された。
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