Identification of periodontitis-associated bone resorption factors in aged mice using RNA-Seq analysis

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19015
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Tohoku University
• Principal Investigator: OKATA Hiroshi 東北大学, 歯学研究科, 大学院非常勤講師 (70709138)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 老化 / 歯周炎 / 歯槽骨吸収 / 網羅的遺伝子解析

Outline of Final Research Achievements

Periodontitis is a disease whose prevalence increases with age and is a major cause of tooth loss in the elderly. Despite this, there have been few reports on the relationship between aging (physiological aging) and periodontitis, and there is little biological knowledge on the effect of aging on periodontitis-associated bone resorption. In this study, the genes expressed in the tissues that experimentally caused periodontitis were comprehensively analyzed and compared between aged and young mice. The results showed that there was no interaction between inflammation caused by periodontitis and aging on alveolar bone resorption, and each was independently involved in alveolar bone resorption. While inflammation due to periodontitis affected the number of osteoclasts, but not aging. It also showed that inflammation-related gene expression increases with periodontitis and immune-related gene expression increases with aging.

Free Research Field

保存治療系歯学関連

Academic Significance and Societal Importance of the Research Achievements

歯周炎に起因する歯槽骨吸収に関する従来の研究の多くは成熟した若い個体を対象にしており、高齢個体における詳細は不明であったが、本研究において、加齢により影響を受ける歯周炎関連骨吸収因子の遺伝子発現パターンを明らかにした。本研究により得られた成果は、歯周炎による歯槽骨吸収の分子メカニズムの解明に貢献するものである。