Efficacy of azithromycin as intracanal medicament in rat extraradicular biofilm model

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19026
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57030:Conservative dentistry-related
• Research Institution: Hyogo Medical University
• Principal Investigator: Yoneda Naomichi 兵庫医科大学, 医学部, 助教 (80781640)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 根尖性歯周炎 / 骨治癒

Outline of Final Research Achievements

Granulocyte colony-stimulating factor (G-CSF) regulates neutrophil survival, proliferation, and differentiation, and activates the function of mature neutrophils, and has also been reported to be involved in bone remodeling. The present study evaluated the effect of G-CSF on bone healing. After intraperitoneal administration of G-CSF to 6-week-old mice for 4 days, unilateral maxillary first molars were extracted, and 6 days later, maxillary bones were harvested. Evaluation by histological observation showed that G-CSF administration resulted in delayed bone healing of the extraction socket.

Free Research Field

根尖性歯周炎

Academic Significance and Societal Importance of the Research Achievements

G-CSFの投与により、骨芽細胞や骨細胞は抑制され、造血幹細胞が放出される。これは骨リモデリング微小環境が破綻しており、これらを解明することは、骨リモデリングが低下した状態の病態解明や診断・治療の進歩に大きくつながると考えられる。