Establishment of the nerve cell culture technique with hydrogel

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19049
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: University of Toyama
• Principal Investigator: IKEDA ATSUSHI 富山大学, 学術研究部医学系, 助教 (00626252)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 唾液腺

Outline of Final Research Achievements

1) We aimed to produce the most suitable material for nerve cell elongation, but we could not obtain the expected results. 2) Using the prepared hydrogel, we searched for the optimal functional peptide-modified hydrogel for the elongation of nerve tissue during tissue culture, and aimed to investigate the mechanism, but we could not achieve it as planned. rice field.
3) We aimed to impart a linear morphology of nerve tissue using hydrogel, which is optimal as a scaffold for nerve cell elongation, but we could not achieve it because it did not proceed as planned.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

本研究にて神経細胞伸長の制御が可能となれば，怪我や手術などによって切断されてしまった末梢神経の修復や神経外傷後の神経障害性疼痛に対する有効な治療手段となり得る．神経切断に伴う運動障害・知覚障害および神経外傷後の神経障害性疼痛などは患者の QOLの低下の要因となるが，生体外にて組織培養した神経組織を生体内に移植することが出来れば，これらのデメリットがなく患者のQOL回復へとつながる画期的な治療法になると考える．今回の研究期間内で明確な研究結果は得られなかったが、今後の研究に繋げていくことを目指していく。