Development of the new bone creation method with the osteoblastic seat derived from a human pulpal stem cell in the implant treatment

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19073
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Tokyo Medical University
• Principal Investigator: MURATA TAKUYA 東京医科大学, 医学部, 兼任助教 (40617718)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: デンタルインプラント / ヒト歯髄幹細胞 / 骨造成

Outline of Final Research Achievements

In this study, Using the human pulp which is the self-cell which I gathered from an unnecessary withdrawal tooth, differentiation guides a pulpal stem cell to the osteoblasts, and this study manufactures the three-dimensional laminating seat and is to establish the new bone creation system.
We divided it into four experimental systems, A, B, C, and D, and made a plan to compare and examine them.
In the bone evaluation, it followed that bone destruction advanced in A group, B group, C group, D group, all groups.As a factor, it was thought that the fixation of the osteoblastic laminated seat being difficult, transplant part gingiva wound part protection being difficult, securing of wound region cleanliness state were difficult.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

デンタルインプラント植立に際して、歯槽骨欠損患者に頻繁に遭遇し骨量確保に苦慮することがある。この骨量確保に対して、自家骨やバイオマテリアルの開発が急速な進歩を遂げている。しかし、その形状、術中の操作性、安全性に難点を有し、人体への侵襲が未だ大く、より安全で簡便な方法はなく問題が残っている。このような問題を解決する方法として、自己細胞であるヒトES細胞、iPS細胞、骨髄間葉系幹細胞などを用いた再生医療が期待されており、本研究も期待できると考えられた。