2022 Fiscal Year Final Research Report
The effect of reducing microbial adhesion to dentures on frailty prevention
| Project/Area Number |
19K19084
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | C.albicans / 義歯性口内炎 / デンチャープラーク / 補綴 / 歯科 |
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| Outline of Final Research Achievements |
We evaluated the effect of peracetic acid for disinfection of C. albicans biofilms formed on denture base resin (PMMA) and the adhesion of C. albicans to the light-cured denture base relining material.
C. albicans biofilms on PMMA were immersed in peracetic acid solution. The amount of biofilm decreased after immersion, and microscopic images showed many dead cells.
The surface properties of the light-cured relining material and the initial adhesion of C. albicans were verified. There was no significant difference in surface roughness compared to other materials, and hardness was higher in the light-cured type. The number of viable cells were decreased.
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| Free Research Field |
歯科補綴学
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| Academic Significance and Societal Importance of the Research Achievements |
近年，身体・認知機能の低下により義歯を十分に清掃できない高齢者は増加している．義歯に付着するバイオフィルムの中でもCandida albicansは義歯性口内炎や誤嚥性肺炎の原因菌となり，付着したバイオフィルムを除去することは同疾患の治療および予防となる．バイオフィルム除去の方法は，ブラシによる機械的清掃と薬液による化学的清掃に大別されるが，高齢の義歯装着者は機械的清掃が不十分な場合も散見される．このような場合は化学的清掃に頼ることになるが，現在までに化学的清掃のみで十分な方法は確立されていない．本研究では新たな義歯清掃方法の開発により高齢の義歯装着者のQoLの改善に寄与できると考える．
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