2023 Fiscal Year Final Research Report
The improvement of existing dental materials and development of new materials for inhibit bone resorption from inflammation.
| Project/Area Number |
19K19134
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
Inamitsu Hiroyuki 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (60779495)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 歯科材料 / 細胞毒性 / 破骨細胞 |
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| Outline of Final Research Achievements |
We already know that dental resin monomer HEMA and TEGDMA have inhibitory effect for osteoclast differentiation from past our works. So we make experiments for identify inhibitory mechanism to use Western blotting, TRAP staining and cell counting at other new materials , but they all have strong cell cytotoxicity and they don't make expression of specific marker about osteoclast differentiation.And it's not uncertain about influence of monomer's structure,maybe they have oxydation stress and fever at the time of polymerization reaction.
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| Free Research Field |
歯科補綴学
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| Academic Significance and Societal Importance of the Research Achievements |
破骨細胞の分化能力を既存の歯科材料およびそれらの構造を改良することで開発できる新規材料により抑制できれば歯周病やその他骨代謝疾患における骨吸収を防止でき、再生療法に貢献できると考える。また毒性を生まずに骨吸収を抑制できれば歯周病に限らず全身における骨のリモデリングを人体に好ましい方向に調整できる可能性がある。今回の研究では歯科用レジンモノマーに限って調査したため期待した効果を得られなかったが今後も様々な化学物質のもつ未解明の効果・機序を解明することで歯科用材料の開発が難病や治療困難な疾患に有意義であることを証明していきたい。
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