2020 Fiscal Year Final Research Report
The influence of quantity and quality of tongue and velum muscles for treatment plan of obstructive sleep apnea
| Project/Area Number |
19K19148
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 57050:Prosthodontics-related
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
Nakamura Yuki 兵庫医科大学, 医学部, 助教 (70781912)
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| Project Period (FY) |
2019-04-01 – 2021-03-31
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| Keywords | 閉塞性睡眠時無呼吸症 / 口腔内装置 / 咽頭腔 |
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| Outline of Final Research Achievements |
Under the influence of COVID-19, we obtained eleven patients' agreement for this study as of 31 March 2021. About eleven patients, we assessed the correlation between results of MRI image analyses(tongue volume, tongue fat mass, tongue lean muscle mass, velum volume, velum lean muscle mass, volume of upper pharynx, e.t.c) and results of sleep test with oral appliance and without oral appliance(respiratory disturbance index, 3% oxygen desaturation index, apnea index, hypopnea index, e.t.c) by Spearman 's rank-correlation coefficient.
Analysis results from Spearman's rank-correlation coefficient didn't reveal significant correlation.
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| Free Research Field |
閉塞性睡眠時無呼吸症，摂食嚥下リハビリテーション
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| Academic Significance and Societal Importance of the Research Achievements |
閉塞性睡眠時無呼吸症(OSA)の歯科的治療法である口腔内装置(OA)の適応症は，歴史的に無呼吸・低呼吸指数(AHI)を指標に決定されてきた．OAは重症には適応ではないとされてきたが，実臨床において，重症であってもOAが奏功する例がある．このことは，OAの適応症判断の指標として，AHIだけを用いることが適切でないことを示唆している．
この点を明らかにしようとすることが本研究の根幹であり，AHI以外の適応症の指標を得ることができれば，より適切にOSAの治療法を選択することが可能となる．これが本研究の学術的・社会的意義である．
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