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2020 Fiscal Year Final Research Report

Whole-genome analysis of the distribution of tandem depulicator, a transcriptional enhancement mechanism in oral cancer

Research Project

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Project/Area Number 19K19153
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionChiba University

Principal Investigator

Miyamoto isao  千葉大学, 医学部附属病院, 医員 (00741836)

Project Period (FY) 2019-04-01 – 2021-03-31
Keywords次世代シーケンス / tandem dupulicator / CNV
Outline of Final Research Achievements

In this study, oral squamous cell carcinoma cell lines were irradiated, and radiation-resistant and radiation-sensitive cell lines were identified. The identified cell lines were analyzed using a next-generation sequence analysis. Based on the results, copy number variation (CNV) were investigated with/without irradiation, and genes specifically expressed in the regions were identified. These results suggested that these genes may be potential targets for further research and target factors in the future.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

口腔癌発生過程においては、多くの遺伝子による系統的な異常が積み重なることが原因であると考えられている。近年、mutationなどの単純な構造異常ばかりではなく、遺伝子配列の繰り返し構造であるtandem duplicator(TD)の全ゲノム上における分布状態やコピー数多型(CNV)が系統的意義を有することが提唱されている。これらは非常に強力な遺伝子発現システムであり、本研究では全ゲノムワイドな解析によりTDやCNVがどのような領域で起きているかを検討し、その分布状況を明らかにし、口腔癌発生や治療抵抗性獲得にどのように関与しているかを検討するという学術的意義が考えられる。

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Published: 2022-01-27  

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