Glutamate as neuro transmitter will be capable to control oral sensation via trigeminal ganglion

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19177
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Tokyo Dental College
• Principal Investigator: NISHIYAMA AKIHIRO 東京歯科大学, 歯学部, 助教 (80550128)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: Glutamate / Trigeminal ganglion / odontoblast / neuro transmitter / TRP channel

Outline of Final Research Achievements

It becomes clear in our study to work as between the odontoblast that Glutamate which is an excitatory neurotransmitter is the constitution of teeth or consecutive communication matter between the cell with the pulpal neuron.
In this report, We suggest that the Ca2+ signal network which assumes glutamate acid a mediator between each cell is built. On the other hand, We might participate in the communication between the cell with Glutamate and the glutamate acid receptor in the communication course with the peripheral nerve, but was unidentified about the course. Advanced to do the elucidation purpose what you controlled with the identification of this course in this study physiologically and identified each glutamate acid receptor which developed in trigeminal ganglion neurons under the pain stimulation.

Free Research Field

神経生理学

Academic Significance and Societal Importance of the Research Achievements

グルタミン酸受容体は神経機能に深く関与しており、象牙質の構成細胞である象牙芽細胞-歯髄ニューロン間での情報伝達がglutamateにより制御されている可能性があり、今後の研究の進展が興味深いところである。本研究成果では三叉神経節細胞に対しての痛み刺激下で特定のグルタミン酸受容体を確定したことで、この受容体を分子標的とする新たな治療開発・創薬が期待され将来性から見ても発展のある研究と考えている。