The identification of genes and miRNAs involved in regeneration using a conduit ligation model mouse

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19200
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: The University of Tokushima
• Principal Investigator: YOKOTA Miho 徳島大学, 病院, 医員 (50836145)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 唾液腺 / 再生 / マイクロアレイ解析

Outline of Final Research Achievements

We try to identify the gene network involved in regeneration of acinar cells by using a conduit ligation mouse model. As a result, we identified Nrep（Neuronal regeneration related protein）as a hub gene involved in the regeneration of acinar cells. We suggest that the regulatory network of stem cells may play an important role for the regeneration of acinar cells.

Free Research Field

口腔外科分野

Academic Significance and Societal Importance of the Research Achievements

本研究結果より，腺房細胞の再生に関わるハブ遺伝子として，腺上皮前駆細胞に特異的に発現する遺伝子(Neuronal regeneration related protein)が同定された．これら同定された幹細胞制御ネットワークが腺房再生に重要な役割を果たしていると考えられた.この成果は、“唾液分泌低下の改善”という患者のQOL向上が期待できるだけでなく、唾液腺疾患への治療応用の可能性も考えられた。