Development of treatments for chemoradiotherapy-induced oral mucositis

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K19207
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Sapporo Medical University (2021-2022); Yokohama City University (2019-2020)
• Principal Investigator: Ohashi Nobuhide 札幌医科大学, 医学部, 助教 (70783752)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 口腔粘膜炎 / プロピルヒドロキシプロリン / 放射線性口腔粘膜炎 / マウス

Outline of Final Research Achievements

Propylhydroxyproline (Pro-Hyp) increased cell proliferation in human oral fibroblasts (HOrF) at a concentration of 200 nmol/mL, which was considered the optimal concentration, as in previous studies. In addition, it was revealed that high-concentration Pro-Hyp inhibited the proliferation of HOrF. It was found that serum components do not significantly affect cell proliferation ability. Radiation alone was investigated because toxicity was high in mice with oral mucositis induced by chemoradiotherapy, making it difficult to continue the study. Administration of Pro-Hyp exacerbated weight loss and tended to exacerbate oral mucositis. Administration of Pro-Hyp at the onset of oral mucositis may promote aggravation of oral mucositis.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

がん化学放射線療法により誘発される口腔粘膜炎に対し，ジペプチドであるプロピルヒドロキシプロリンの効果を検討した。プロピルヒドロキシプロリンはヒト口腔線維芽細胞に対し，細胞増殖の増大効果を有していたが，マウスで口腔粘膜炎を発症させると増悪させる可能性があることがわかった。