Development of biomarkers and therapeutic target molecules for salivary gland tumors

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19213
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Nihon University
• Principal Investigator: YAMAMOTO Hiroshi 日本大学, 松戸歯学部, 講師 (80459586)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 唾液腺腫瘍 / 免疫組織化学染色 / 多形腺腫

Outline of Final Research Achievements

Pleomorphic adenomas occurring in the palatal gland were subjected to histopathological classification according to the Seifert classification, and immunohistochemical analyses were performed. The study highlights a strong correlation between Seifert's classification and the ratio of tumor-forming myoepithelial cells near the capsule. Cellular type demonstrated the highest IRS, suggesting heightened biological activity, which is supported by SOX- 10 and EGFR staining patterns. This study suggests a link between Seifert’s classification and biological activity in minor salivary gland pleomorphic adenomas. Cellular type exhibited a potential for higher biological activity, based on staining patterns and IRS.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

多形腺腫は被膜を有するが、被膜が不完全なことや被膜内に浸潤を認めることがあるため、病理組織学的な検索では腫瘍細胞と被膜との関係性を明らかにすることが重要である。
本研究の成果から、口蓋腺における多形腺腫においては被膜近傍の腫瘍組織はSeifert分類による組織型と生物学的活性との関係性が示唆された。特に, cellular-rich typeはSOX10とEGFRの染色態度に鑑み腫瘍細胞の増殖・分化といった生物学的活性が高い可能性が示唆された。