Establishment of novel genetic diagnostic technology for selecting optimal treatment for odontogenic tumors

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K19252
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Kindai University
• Principal Investigator: Toyodome Soichiro 近畿大学, 奈良病院, 助教 (20836663)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 口腔外科 / 角化嚢胞 / エナメル上皮腫 / 歯原性腫瘍

Outline of Final Research Achievements

The purpose of this study was creating criteria for reliable treatment selection for odontogenic tumors and to explore the possibility of treatment using gene therapy. First, it was necessary to find cases suitable for this study and collect specimens, so we collected samples as appropriate, but it took time due to the long-term coronavirus pandemic. Furthermore, we searched past cases and collected data of recurrence. Among these, there are rare odontogenic tumors that have been pointed out to be recurrence in the future, and jawbone-centered cancers that are thought to have arisen from malignant transformation of odontogenic tumors, and whose course cannot be tracked over the long term. After summarizing these findings and considering the literature, we presented them in papers and at academic conferences.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

歯原性腫瘍はこれまでその多くが良性腫瘍として扱われており、治療法も摘出が基本であった。一方で、再発や悪性化を生じる症例も指摘されており、初期に適切な治療が行われなかった場合、予後に不安を残す可能性もある。今回の研究では、この予後を踏まえて初期治療の段階でどのように治療を行うのが良いか、客観的な指標を作ることが将来的な目標であった。研究中にも予後不良とされる症例や悪性化を疑う症例が見られたため、いずれも検索と考察を行い論文や学会にて発表した。