Elucidation of COX inhibition mechanism by acetaminophen for clinical application to reduction of root resorption

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K19296
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Hiroshima University
• Principal Investigator: Yamamoto Taeko 広島大学, 医系科学研究科(歯), 研究員 (10823198)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 歯根吸収 / アセトアミノフェン / 歯髄細胞

Outline of Final Research Achievements

The present study aimed to investigate the inhibitory effect of acetaminophen on apical root resorption during orthodontic tooth movement by controlling inflammation in the apical pulp tissue. The results showed the expression levels of inflammatory cytokine and osteoclast differentiation factor were significantly higher than in the control group of the inflammatory pulp cell. However, the expression levels of these factors were decreased by acetaminophen administration through COX inhibition. High expression of inflammatory cytokine and osteoclast differentiation factor at the root apex were also detected immunohistochemically in rats after tooth movement, but were decreased by acetaminophen administration.

Free Research Field

矯正歯科

Academic Significance and Societal Importance of the Research Achievements

アセトアミノフフェンの抹消でのメカニズムを明らかにすることは学術的創造性が高く、矯正歯科治療において、より安全性の高い薬剤による歯根吸収の抑制が可能となり、臨床上きわめて価値が高いものと考えられる。そして、硬組織の吸収は歯根のみならず、人体の様々な部位で認められる現象のため他の病態の治療にも繋がる可能性があり、歯科医学の進歩に大きな貢献を果たすものと考えられる。