Investigation about effects of exercise and nutrition intervention on activity of daily living improvement in a rehabilitation hospital

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19939
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: Kawamura Koki 国立研究開発法人国立長寿医療研究センター, 病院, 理学療法士 (30812416)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: サルコペニア / 栄養 / 回復期リハビリテーション / フレイル / 身体機能 / 活動量

Outline of Final Research Achievements

The purpose of this study is to examine sarcopenia and nutritional status improvement in a rehabilitation ward. Patients with musculoskeletal disease admitted to a rehabilitation ward received 6 g/day of Branched Chain Amino Acids in addition to exercise. Sarcopenia and nutrition status were assessed at admission, discharge, and one month after discharge. There were 42 subjects (mean age 80.3 years), the prevalence of sarcopenia was 36% at admission, 38% discharge and 18% one month after discharge, and low nutrition was 55% at admission, 51% discharge and 42% one month after discharge. The results suggest that sarcopenia and nutritional status may improve after discharge, although not significantly during admission. In the future, we will conduct a comparison using a randomized control trial design that includes the follow-up period after discharge from the hospital.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

回復期患者は疾患や入院生活中の低活動などの影響によりサルコペニアや低栄養の割合が多く筋肉量や栄養状態改善のための積極的な介入が必要である。今回は対照群の設定がなく栄養剤付加による効果の立証に至ってはいないが、回復期退棟後にも変化が現れる可能性が示唆された。今回の結果をもとに今後対象疾患や栄養剤付加量の検討、退棟後のフォロー期間を含めたRCTデザインによる比較等を行っていくことで、回復期患者のサルコペニア、栄養状態をより改善させる方策の立案に繋がるものと考える。なお、これまでの結果については関連学会での発表を行っており、最終的には国内外の学術雑誌に論文投稿を行う予定である。