Bogy weight set point reset effect by exercise: Energy metabolism control mechanism of skeletal muscle UCP3

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20125
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Nihon University
• Principal Investigator: SHINDO Daisuke 日本大学, 薬学部, 准教授 (80748096)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: Ucp3 KOマウス / 幼若齢期運動 / 体重量 / エネルギー消費量

Outline of Final Research Achievements

Using Ucp3-deficient (KO) mice, we investigated the effects of exercise during the early to adolescent period on body weight and energy expenditure up to the middle and old age equivalent of humans. Spontaneous exercise using a rotating cage from 5 to 17 weeks of age, followed by free feeding and resting until 29 weeks of age WT and KO mouse instar exercise group, resting until 5 to 29 weeks of age It was divided into the resting maintenance group.
Regarding the body weight, the WT mouse instar exercise group maintained a significantly lower value than the rest maintenance group even if it was maintained at rest after the exercise was stopped. The energy consumption of the WT mouse resting group was significantly higher than that of the KO mouse resting group.

Free Research Field

栄養学および健康科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、体重のセットポイント低下ならびにエネルギー代謝亢進にUCP3が関与している可能性が示された。また、ヒト幼若齢期相当期間の運動によって、運動介入解除後の自由摂食・安静維持下でも体重増加が抑制された。
これらは、小児から青年期にかけての運動の重要性を示す科学的エビデンスであり、啓発活動をするうえで大変有益な結果である。