2021 Fiscal Year Final Research Report
Involvement of colon-luminal polyamines in insulin secretion. An approach to the prevention of diabetes mellitus
Project/Area Number |
19K20173
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 59040:Nutrition science and health science-related
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Research Institution | Kyodo Milk Industry Co., Ltd. |
Principal Investigator |
Ikuta Kayo 協同乳業株式会社研究所, 研究所, 研究員 (10836232)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | ポリアミン / 腸内細菌 / 糖尿病 |
Outline of Final Research Achievements |
The effects of polyamines produced by colonic microbiota on the body and diabetes mellitus were investigated. In the balance test, feces contained a larger amount of polyamines than the amount of dietary polyamines. When stable isotope-labeled polyamine was injected into the colon lumen, about 60% of the administered amount was transferred to the body by polyamine depletion treatment. In the high-fat diet induced diabetic mouse model, changes in intestinal tissue site-specific polyamine concentration and intestinal endocrine cell-related gene expression were observed.
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Free Research Field |
栄養学
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、正常な細胞機能の維持に不可欠なポリアミンに着目し、特に、食事に劣らないポリアミン供給源である腸内細菌由来ポリアミンの糖尿病予防への有効性を検討した初めてのものである。糖尿病モデルでみられた腸管組織中ポリアミン濃度減少を腸内細菌によるポリアミン供給で改善することができれば、腸上皮細胞健全性を維持し続けることができる可能性がある。これは糖尿病発症や進行遅延の新しいターゲットとなることが期待できる。
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