Analysis of interaction between skeletal muscle satellite cells and macrophages for maintenance of tissue homeostasis

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20178
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Nippon Medical School
• Principal Investigator: Koike Hiroyuki 日本医科大学, 医学部, 助教 (20821771)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: 骨格筋 / マクロファージ / 再生 / 炎症 / サルコペニア

Outline of Final Research Achievements

Aging-related loss of skeletal muscle mass, sarcopenia, develops with a muscle regeneration deficiency and is one of the major factor in reducing physical fitness. In damaged muscle tissue, the tissue inflammation and repair which are mainly composed of skeletal muscle satellite cells, occur, and it is essential that they are properly controlled during muscle regeneration. However, the actual state of the control mechanism is unclear. In this study, based on single-cell analysis, we attempted to analyze the molecular mechanism that controls muscle regeneration while muscle satellite cells and macrophages cooperate with each other from a spatiotemporal perspective. The findings obtained from this study are expected to deepen the understanding of the disruption of muscle regeneration caused by aging and metabolic disorders, and lead to the identification of new therapeutic target molecules.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

サルコペニアは体力や身体機能の低下を招き、高齢者の Quality of Life を低下させる。その予防・治療法の開発は本邦において急務の課題である。本研究では、筋衛星細胞とマクロファージとで交わされる時空間的な制御機構に焦点を当てながら、この課題解決を試みた。本研究により得られた知見は、骨格筋組織再生不全に起因する現象についての理解を深め、新たな治療標的分子の同定につながることが期待される。