Integrated biokinetic model for administration of decorporation agents (DTPA) for actinide intake

2020 Fiscal Year Final Research Report

• Project/Area Number: 19K20453
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 63020:Radiation influence-related
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Tani Kotaro 国立研究開発法人量子科学技術研究開発機構, 高度被ばく医療センター 計測・線量評価部, 研究員(定常) (40736071)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Keywords: アクチニド元素 / 体内動態モデル / 体内除染剤

Outline of Final Research Achievements

In this study, the system of differential equations describing biokinetics of the radionuclides incorporated in the body according to the respiratory model (ICRP Publ. 130), the alimentary model (ICRP Publ. 100) and the metabolic model for actinide elements (ICRP Publ. 141) was numerically analyzed. Moreover, the process of producing Am/Pu-DTPA in blood, interstitial fluid and lymph was integrated by introducing the metabolic model of DTPA which is decorporation agents for actinide elements. As a case study of an accidental inhalation of Am-241, the chemical form and particle size of the Am-241 compounds were determined by analyzing the results of individual monitoring and promotion of urinary elimination of Am-241 by DTPA administration was roughly reproduced.

Free Research Field

放射線防護

Academic Significance and Societal Importance of the Research Achievements

放射性化合物の摂取を伴う事故において、必ずしもその化学形や粒径に関する情報が得られるとは限らない。本研究の成果は、放射性化合物を摂取した個人を対象として実施する体外計測やバイオアッセイなどのモニタリング結果に基づく化学形及び粒径の推定を可能とし、妥当な内部被ばく線量の提供に役立つものである。また、本研究で構築したDTPA投与後の体内動態モデルの実用化が、投与の必要性や被ばく線量の低減効果の評価につながるものと期待される。