Personalized optimization of interatrial shunt device to prevent heart failure

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20690
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Nishikawa Takuya 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員 (50823861)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 心房間シャント / 心不全 / 循環動態

Outline of Final Research Achievements

Interatrial shunt devices can reduce left atrial pressure and pulmonary congestion by shunting blood flow to the right atrium, but clinical trials have not demonstrated a clear prognostic benefit. We conducted a study to predict the impact of interatrial shunt devices to optimize the use of these devices.
Using circulatory equilibrium framework, we developed a system to predict impact of interatrial shunting on hemodynamics. We created an interatrial shunt in a large animal (mongrel dog) and confirmed that the predicted hemodynamics agreed accurately with measured values. In addition, we validated the theory using chronic shunt model.

Free Research Field

心不全、循環動態、心臓識学

Academic Significance and Societal Importance of the Research Achievements

本研究は心房間シャントデバイスの最適化に向けて、個別の循環動態の効果を事前に予測する試みである。本研究は患者個別に心房間シャントの血行動態的影響を明らかにするもので、適応・サイズ選択を最適化する。個別にリスク・ベネフィットを最適化することにより、従来実証できなかった予後改善効果へとつながることが期待できる。