Development of brain tumor-targeted drug delivery system using microbubbles and ultrasound

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20717
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: Teikyo University
• Principal Investigator: Omata Daiki 帝京大学, 薬学部, 講師 (80803113)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: マイクロバブル / 超音波 / 脳腫瘍 / ドラッグデリバリー

Outline of Final Research Achievements

We demonstrated that the combination of microbubbles and ultrasound could induce the blood brain barrier opening in the tumor tissue in mouse model for brain tumor. We evaluated the cisplatin delivery to the brain tumor using the combination of microbubbles and ultrasound. As a result, the cisplatin amount in brain tumor in the treatment of cisplatin with microbubbles and ultrasound was higher than that of treatment of cisplatin alone. In addition, we assessed the therapeutic effects of the treatment of cisplatin with microbubbles and ultrasound for brain tumor. The duration of survival was prolonged by the treatment of cisplatin with microbubbles and ultrasound. Our results suggested that the combination of microbubbles and ultrasound could efficiently deliver anti-cancer drug to the brain tumor and enhance the anti-tumor effect.

Free Research Field

薬剤学

Academic Significance and Societal Importance of the Research Achievements

マイクロバブルと超音波を用いた血液脳関門オープニング技術が注目されているが、脳腫瘍モデル動物での研究は十分に進められていない。本研究では、脳腫瘍マウスモデルにおいて、マイクロバブルと超音波による抗がん剤デリバリー技術を確立し、脳腫瘍治療効果を得ることに成功した。本研究で得られた知見は、脳腫瘍治療戦略の構築に貢献すると期待される。