Development of method to detect thermal denaturation induced by ultrasound using acoustic cavitation signals

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20725
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 90130:Medical systems-related
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Takagi Ryo 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (20771885)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 超音波治療 / 超音波診断 / 音響キャビテーション / 圧電

Outline of Final Research Achievements

This research was conducted to improve the accuracy of an ultrasound diagnosis technique to support the ultrasound treatment, which is not widely used in Japan. It is generally difficult to detect the ultrasound-treated region where there are cavitation (boiling at room temperature) bubbles using the diagnostic ultrasound. In this study, the new ultrasound diagnosis technique was developed to　noninvasively detect the ultrasound-treated area even if there are cavitation bubbles in the tissue during ultrasound treatment. The accuracy of an ultrasound diagnosis could be better than a conventional method by using our technique which is focused on the reflected ultrasound signals from the cavitation bubbles.

Free Research Field

超音波工学

Academic Significance and Societal Importance of the Research Achievements

本研究は、これまで解明されていなかった、超音波治療部位に生じた、たんぱく変性、キャビテーション気泡生成と診断用超音波信号変化の関係を明らかにした点で、学術的意義がある。その関係から、超音波治療における、超音波診断技術の精度を向上させることができた点で、超音波診断における新しい技術の創生と現状の超音波治療機器の普及拡大の観点から社会的意義があると考える。