A new treatment method of femoral head plasty for onteonecrosis of the femoral head

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21114
• Project/Area Number (Other): 18H05958 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Nagoya University
• Principal Investigator: Osawa Yusuke 名古屋大学, 医学部附属病院, 医員 (40822812)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 大腿骨頭壊死

Outline of Final Research Achievements

As for BKP for human femoral head, it is difficult to mechanically reduct the collapsed part after a long time after crushing the head. It is easy to damege the balloon.Therefore, it is necessary to greatly improve the material of balloon.
In model mice, we focused on the fact that the new bone performance was enhanced by constitutive activation of FGFR3 (chondrodysplasia), and it was applicable to bone regeneration at the necrotic part of the femoral head. Imaging and histological and micro-CT evaluations were performed on achondroplasty and wild-type mice to quantify necrotic and new bone in the condyle of the femoral. As a result, in the achondroplasia mice, the collapse of the necrotic part tended to be small, and in the Tunel staining, the necrotic part tended to regenerate quickly.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

本研究の結果では骨壊死部に対する骨頭形成は力学的な観点が問題と考えられた。難治性疾患である大腿骨頭壊死は若年者のQOLを著しく損なう疾患であり、素材の改良を加えることでより低侵襲で簡便な治療法の確立が期待される。
FGFR3を用いた骨壊死組織のリモデリングは本研究の結果からも一定の効果があることが示唆された。さらなる研究の継続により、分子学的な機序の解明できることが今後の目標である。