Quantitative tissue oxygen measurement for early diagnosis of Peripheral arterial disease

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21118
• Project/Area Number (Other): 18H05964 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Nagasaki International University
• Principal Investigator: Enomoto Ayano 長崎国際大学, 薬学部, 助教 (30826186)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: オーバーハウザー効果MRI / アレイコイル / 磁気共鳴

Outline of Final Research Achievements

The knowledge of the distribution of free radicals in animal body is important for understanding and diagnosis the pathology of free radical related diseases such as inflammation and ischemia/reperfusion injury. Overhauser enhanced MRI (OMRI) is the one of the method to obtain the distribution of free radicals non-invasively with anatomical image. Moreover, OMRI imaging with free radical probes can obtain the functional parameters such as pO2 in animal body, which are important for diagnosis of many diseases such as peripheral arterial disease (PAD). However, since the visualization area of the conventional OMRI was limited, the expansion of OMRI imaging area is required to obtain larger visualization area for practical in vivo pO2 measurement. The main purpose of this study was to extend the visualization area in OMRI to enable the observation of the distribution of pO2 in large area of animal body. To achieve this, we developed multi-channel array coil for OMRI imaging.

Free Research Field

医用工学

Academic Significance and Societal Importance of the Research Achievements

本研究では末梢動脈疾患において、虚血状態にある四肢の酸素分圧の新規測定手法の構築を目的とした。そのために従来達成されていなかった、オーバーハウザー効果MRIにおける広範囲かつ高感度な測定を可能にするため、OMRI法に適したマルチコイルアレイを開発した。また新規に作成したコイルアレイが、生体適用が可能であることを実証した。
これは、今後のOMRI計測法でのの汎用性を高めたという点で重要である。また、本研究で開発したアレイコイルは、最終的な目標である虚血肢の早期診断のための酸素分圧測定を可能にするという点で社会的にも意義がある。