2019 Fiscal Year Final Research Report
Search for new biologically active compounds based on viral-fungal interaction
| Project/Area Number |
19K21142
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| Project/Area Number (Other) |
18H05999 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0601:Agricultural chemistry and related fields
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | イネいもち病菌 / マイコウイルス / 二次代謝 / テヌアゾン酸 |
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| Outline of Final Research Achievements |
Fungal genome contains a large number of biosynthetic genes for secondary metabolites, most of which are hardly expressed under normal laboratory conditions. We focused on mycoviruses as an inducer of such silent genes, and searched for secondary metabolites, the production of which is promoted by viral infection. As a result, we discovered totivirus-induced mycotoxin production in a rice blast fungus. Furthermore, transcriptome analysis indicated the transcriptional regulatory mechanism of the biosynthetic gene for the toxin associated with viral infection.
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| Free Research Field |
天然物化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は世界で初めて，ウイルス感染に伴って，糸状菌の二次代謝産物の生合成遺伝子の発現が転写レベルで正に調節されることを確認した。一部のウイルスは菌糸融合等の手法によって容易に糸状菌に導入可能であることが確認されている。従って本研究は，物質産生を活性化する内在性の因子としてウイルスを物質生産や物質探索に応用できる可能性を示す。
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