2019 Fiscal Year Final Research Report
The relationship between microglia and depression in a mouse model of social defeat stress
| Project/Area Number |
19K21213
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| Project/Area Number (Other) |
18H06091 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | うつ病 / ミクログリア / 炎症 |
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| Outline of Final Research Achievements |
Recent studies raised the possibility that neuroinflammation relates to the pathophysiology of depression following social stress.In this study, we aimed to elucidate the relationship between depression and microglia, resident immune cells in the brain, using a social defeat (SD) stress model mouse.Depression-like behavior and anxiery-like behavior were increased by exposure to SD stress for 10 days.SD stress increased the numerical densities of microglia in the hippocampus.The numbers of nodes, ends, and total lengths of microglial process were decreased by SD stress. In addition, we analyzed the potential effect of soy isoflavone genistein, which has anti-inflammatory effect. Genistein administration partially decreased depression-like behaviors and neuroinflammation caused by SD stress.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
うつ病の生涯罹患率は3～15%との報告もあり、頻度の高い精神疾患である。うつ病患者の治療において、セロトニンやノルアドレナリンの再取り込み阻害薬等が第一選択薬として用いられている。それらには一定の治療効果が認められているが、治療が奏功せず、難治化する患者が一定の割合で存在することも報告されており、新たな病態の理解と治療戦略の創出が重要な課題になっている。本研究は、社会的ストレスによる行動変化とともにミクログリアの詳細な形態変化を明らかにし、うつ病の発症や回復におけるミクログリアの重要性について理解を深めるものである。
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