2019 Fiscal Year Final Research Report
Advanced Diagnostic Imaging of Pediatric Brain Tumor using Multiparametric MRI
| Project/Area Number |
19K21273
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| Project/Area Number (Other) |
18H06164 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0901:Oncology and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | 小児脳腫瘍 / multiparametric解析 / 拡散強調画像 / 動脈スピンラベル法 / 化学交換飽和移動 / stretched-DWI / IVIM |
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| Outline of Final Research Achievements |
Pediatric brain tumors are the second most common type of cancer in children, and their type and frequency differ greatly from adult brain tumors, and there are also special characteristic tumors only in children, those reasons make their preoperative diagnosis still difficult. This study aims to establish a more advanced and accurate preoperative diagnostic method for pediatric brain tumors by combining various MRI sequences, and our results demonstrated that the combination of the diffusion coefficient “D” and perfusion fraction “f” calculated from intravoxel incoherent motion (IVIM), was optimal for preoperative diagnosis. Since this method is non-contrast way, which is considered to be useful not only for preoperative diagnosis but also for therapeutic effect and follow-up disease
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| Free Research Field |
神経放射線医学
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| Academic Significance and Societal Importance of the Research Achievements |
治療戦略にとって術前画像診断は重要であるが、本研究により最適な術前画像診断が可能となることで、画像診断技術の高度化につながるだけでなく、小児脳腫瘍の治療法の進歩につながる。術後画像診断として、治療効果判定や予後予測の一助となる。さらには、経過観察時の診断においても、非侵襲的に繰り返し行うことが可能であるため、造影剤の省略ないしは減少が期待され、将来的な医療費抑制効果も期待される。
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