The dynamics of endothelial microparticles in ventilator related lung injury (VILI) and the effect of sevoflurane on endothelial injury n VILI

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21335
• Project/Area Number (Other): 18H06236 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0905:Surgery of the organs maintaining homeostasis and related fields
• Research Institution: Tohoku University
• Principal Investigator: TAKEI YUSUKE 東北大学, 大学病院, 助教 (80822890)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 人工呼吸関連肺傷害 / 内皮微小粒子 / 血管内皮傷害

Outline of Final Research Achievements

We reported that lung-derived circulating Endothelial Microparticles (EMPs) increased in acute lung injury, reflecting pulmonary endothelial injury. Furthermore, it were strongly correlated with the severity of vascular hyper-permeability in acute lung injury. In addition, we showed that the number of circulating EMPs increased in patients with sepsis, and that PECAM+EMPs and VE-cadherin+EMPs could be a novel indicator of vascular hyper-permeabilitiy. We established more stable VILI rat model by administering muscle relaxants to eliminate the effect of spontaneous breathing with precise ventilator that enables high volume ventilation of 20 ml / kg accurately for small animals.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

本課題では、内皮微小粒子(endothelial microparticles: EMPs)が敗血症や急性肺傷害の内皮傷害を反映し、新たな血管内皮マーカーとなり得ることを示した。特に、PECAM+EMPsやVe-cadherin+EMPsは血管透過性亢進の指標になり得ることが示唆されており、人工呼吸関連肺傷害(VILI)の内皮傷害の病態の解明、セボフルランを含めたVILIに対する新規治療の効果判定に役立てられることが期待される。