Research for physiological function and epileptogenesis by analysis of high frequency oscillations and phase amplitude coupling using scalp electroencephalography

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21356
• Project/Area Number (Other): 18H06264 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: Juntendo University
• Principal Investigator: Iimura Yasushi 順天堂大学, 医学部, 助教 (30819222)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: てんかん / 脳波解析 / 高周波律動 / phase amplitude coupling

Outline of Final Research Achievements

Modulation index (MI) reflects the degree of pathological and physiological phase-amplitude couplings between high frequency oscillations (HFOs) and slow waves in electrocorticography. Children with epileptic spasms (ES) had high values of MI in the intracranial video EEG (Iimura et al., 2018). We explored the MI of interictal epileptic discharges on scalp EEG of a patient with ES secondary to a posterior quadrant leptomeningeal capillary malformation of Sturge-Weber syndrome (SWS), who underwent two-staged surgery. We concluded that decremental MI on scalp EEG could predict good seizure outcome in this patient with SWS and ES.

Free Research Field

てんかん脳波解析

Academic Significance and Societal Importance of the Research Achievements

頭皮脳波におけるてんかん外科術後の発作予後予測biomarkerの確立が求められている。本研究において、頭皮脳波におけるphase amplitude coupling解析の有用性が示唆されたことから、今後の難治性てんかん患者への応用が期待され、てんかん患者の発作予後改善に寄与することが期待される。