2019 Fiscal Year Final Research Report
Elucidation of the mecanism in extra-capsular extension (ECE) of lymph nodes in oral cancer metastasis
| Project/Area Number |
19K21410
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| Project/Area Number (Other) |
18H06326 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0907:Oral science and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Keywords | 口腔癌 / リンパ節転移 / 節外進展 |
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| Outline of Final Research Achievements |
It is known that the presence or absence of extranodal extension is an important factor for the prognosis of the patients with lymph node metastasis of oral squamous cell carcinoma. However, the molecular mechanism controlling extranodal extension in lymph node metastatic lesions has not yet been clarified. In this study, analysis using clinical samples and lymph node metastasis models of oral cancer was performed. We established oral cancer cell lines labeled with a fluorescent protein not only in human oral cancer cells but also in mouse cancer cells. We believe that the combined use of the model animal established by this study and the analysis of clinical specimens of oral cancer will contribute to the elucidation of the molecular mechanism of the extranodal extension of oral cancer metastases and the development of new molecular targeted therapies.
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| Free Research Field |
癌転移
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| Academic Significance and Societal Importance of the Research Achievements |
口腔癌の頸部リンパ節転移における節外進展に関しては、臨床検体を用いた疫学的研究を中心に多くの研究がなされてきたが、その分子生物学的メカニズムに関する研究はほとんどなされておらず、国内外において報告がない。本研究成果により免疫不全マウスだけでなく正常な免疫を有したマウスでのモデルを用いることが可能となり、さまざまな状況下での転移リンパ節と原発巣の解析を臨床検体ならびに動物実験モデルを用いて分子生物学的なアプローチで解析することが可能となった。本研究により得られた成果は、リンパ節転移における節外進展のメカニズムを解明するとともに口腔癌転移の制御に向けた基礎的知見となることが期待される。
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