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2020 Fiscal Year Final Research Report

Status in the prevalence of antimicrobial-resistant bacteria among healthy people as reservoir

Research Project

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Project/Area Number 19K21486
Project/Area Number (Other) 18H06407 (2018)
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund (2019)
Single-year Grants (2018)
Review Section 0908:Society medicine, nursing, and related fields
Research InstitutionRakuno Gakuen University (2020)
Osaka Institute of Public Health (2018-2019)

Principal Investigator

Fukuda Akira  酪農学園大学, 獣医学群, 助教 (90827320)

Project Period (FY) 2018-08-24 – 2021-03-31
Keywords耐性菌 / モニタリング / リザーバー / 健康保菌 / セファリスポリン / キノロン / 耐性遺伝子 / コリスチン
Outline of Final Research Achievements

Antimicrobial-resistant bacteria monitoring is limited in nonclinical settings (short periods and resistance against specific antimicrobials). This study elucidated the trends in the prevalence of ARB and the dissemination of specific antimicrobial-resistant pandemic clones among healthy people in non-clinical settings. We isolated the 517 Escherichia coli from healthy individuals in Japan between 2013-2019 and measured the susceptibility to several types of antimicrobials.
Resistance rates to cephalosporins increased after 2017 compared with those until 2016. Resistance rates to ciprofloxacin > 15%, respectively, after 2016, except in 2017. Compared with JANIS which is a Japanese national surveillance of nosocomial infections in hospital, antimicrobial resistance rates in this study was low. However, the trends of resistance to fluoroquinolones and cephalosporins in non-clinical settings (this study) were similar to those in clinical settings (JANIS).

Free Research Field

耐性菌

Academic Significance and Societal Importance of the Research Achievements

長期間のサーベンランスにより市中の健常者における耐性菌のトレンド・現状を明らかにすることが出来た。耐性菌による感染症が問題となっている病院内よりも耐性菌の保有割合は低率であるが、医療上重要な抗菌薬に対する耐性割合が増加傾向にあり、病院由来株と同様の傾向が観察されたことからヒト社会での耐性菌の循環・維持の可能性が示唆された。

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Published: 2022-01-27  

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