2020 Fiscal Year Final Research Report
Longitudinal study to elucidate factors related to skeletal muscle degeneration in patients with knee osteoarthritis
| Project/Area Number |
19K21493
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| Project/Area Number (Other) |
18H06416 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2021-03-31
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| Keywords | 変形性膝関節症 / 骨格筋変性 / 筋質低下 |
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| Outline of Final Research Achievements |
Echo intensity of the vastus medialis using ultrasound imaging and the extracellular-to-intracellular water (ECW/ICW) ratio using bioelectrical impedance analysis characterised quadriceps muscle degeneration in knee osteoarthritis (OA). These indices are helpful clinical signs for detecting muscle degeneration in patients with knee OA. In addition, our findings indicate that higher ECW/ICW ratios are associated with greater functional disability in patients with knee OA. However, the relationship between gait characteristics and longitudinal changes on skeletal muscle degeneration could not be concluded due to the limited number of participants.
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| Free Research Field |
リハビリテーション科学
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| Academic Significance and Societal Importance of the Research Achievements |
変形性膝関節症（膝ＯＡ）患者における大腿四頭筋の筋機能低下は、機能障害の悪化だけでなく、ＯＡ進行に影響する。そのため、筋機能低下の要因を探索することは、予防的・治療的観点から重要な課題であった。本研究の結果は、従来より膝ＯＡ患者の筋機能低下に関連するとされていた筋萎縮よりも筋質低下による影響が大きいことを明らかにした。また、この評価方法は、超音波画像診断装置や生体電気インピーダンス法によって非侵襲的かつ簡便に計測できる技術を活用した成果であり、臨床活用の普及に期待できるものである。
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