Identification of adipokines involved in reducing arterial stiffness by exercise training, and elucidation of molecular mechanisms

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21499
• Project/Area Number (Other): 18H06423 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Ritsumeikan University
• Principal Investigator: Hasegawa Natsuki 立命館大学, 総合科学技術研究機構, 研究員 (00822850)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: アディポカイン / 動脈硬化 / 脂肪 / 有酸素性トレーニング

Outline of Final Research Achievements

This study investigated the identification of adipokines involved in reducing arterial stiffness by exercise training. Obesity model mice were divided into sedentary control and aerobic exercise training (voluntary wheel running) groups. Aerobic exercise training significantly increased adiponectin and CTRP3 mRNA expression in epididymal adipose tissue, and significantly improved endothelial function. Additionally, transplantation of epididymal fat from aerobic-trained mice into sedentary control mice revealed that reduction of arterial stiffness. These results suggest that the aerobic exercise training-induced increase in the production of adiponectin and CTRP3 from local adipose tissues may be associated with a reduction in arterial stiffness.

Free Research Field

運動生理・生化学

Academic Significance and Societal Importance of the Research Achievements

本研究により，習慣的な運動により局所的に存在する脂肪組織から産生されるアディポカイン：CTRPs が動脈血管に作用することを明らかにしたことで，「臓器間のネットワーク」による新たな運動効果の機序を提案することができる。また，全身のどこに蓄積する脂肪を改善させることが動脈硬化に対して効果的なのかを明らかにすることで，将来的には，肥満患者における心血管系疾患リスクの増大の予防・改善のための科学的な根拠に基づく運動プログラムの構築への応用が期待できる。