The relation between hypertension-related cognitive decline and neural insulin signaling

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21507
• Project/Area Number (Other): 18H06432 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: Fukui Yusuke 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 研究員 (60824802)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 認知機能障害 / 糖尿病 / 高血圧 / 糖代謝

Outline of Final Research Achievements

Middle-aged type2 diabetes (T2DM) model mice showed increased blood lipid level, cognitive impairment, and changes of glucose metabolism-related signaling factors without Aβ alteration. On the other hand, STZ-induced -type1 diabetes (T1DM) mice also showed cognitive impairment, however, no change of glucose metabolism-related signaling factors and Aβ level was observed. Moreover, middle-aged APPKI mice with increased Aβ level showed change of glucose metabolism-related signaling together with cognitive decline.

Free Research Field

神経内科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、栄養代謝異常を持つ認知機能障害モデルマウスを用いて、脳の糖代謝調節経路および代謝の変化と認知機能の関係について解析したもので学術的・社会的意義が深い。