Molecular analysis of cellular stress response in fatigue model mice

2019 Fiscal Year Final Research Report

• Project/Area Number: 19K21517
• Project/Area Number (Other): 18H06446 (2018)
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund (2019); Single-year Grants (2018)
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kanazawa Medical University
• Principal Investigator: AKAI Ryoko 金沢医科大学, 総合医学研究所, 助手 (60823317)
• Project Period (FY): 2018-08-24 – 2020-03-31
• Keywords: 疲労 / ストレス / 生体イメージング

Outline of Final Research Achievements

We are interested in mechanisms of biological defense, and have researched them for the last dozen years. Until now we have developed some model mice for imaging analysis of cellular stresses in vivo, and found relationship with various diseases. Cellular stress and inflammation are recently thought to have some connection to “fatigue”, but it is poorly understood. Here we applied fatigue loading (sleep deprivation) to our model mice, and analyzed these stress responses by in vivo imaging. As results, we can discovered that ER stress response (IRE1), integrated stress response (ATF4), and inflammatory response (IL-1β) were activated in the adrenal glands by sleep deprivation.

Free Research Field

実験動物学

Academic Significance and Societal Importance of the Research Achievements

本研究は疲労が生じる際や回復する際の仕組みを分子／細胞生物学的観点から解明することにアプローチするべく行われてきた。疲労に苦しむ人々は非常に多く、これは現代社会において決して無視できない大きな問題であり、その解決の糸口となることを目指していることが本研究の大きな意義である。この研究から明らかになることが単に基礎的な生命科学へ貢献するだけでなく、疲労が生む社会問題（健康障害から事故・自殺に至るまで）に対する解決への糸口になる可能性を十分に含んでいる。